Identification of microRNA precursors with new sequence-structure features
نویسندگان
چکیده
منابع مشابه
Identification of microRNA precursors with new sequence-structure features
MicroRNAs are an important subclass of non-coding RNAs (ncRNA), and serve as main players into RNA interference (RNAi). Mature microRNA derived from stem-loop structure called precursor. Identification of precursor microRNA (pre-miRNA) is essential step to target microRNA in whole genome. The present work proposed 25 novel local features for identifying stemloop structure of pre-miRNAs, which c...
متن کاملIntegrated Sequence-Structure Motifs Suffice to Identify microRNA Precursors
BACKGROUND Upwards of 1200 miRNA loci have hitherto been annotated in the human genome. The specific features defining a miRNA precursor and deciding its recognition and subsequent processing are not yet exhaustively described and miRNA loci can thus not be computationally identified with sufficient confidence. RESULTS We rendered pre-miRNA and non-pre-miRNA hairpins as strings of integrated ...
متن کاملStructure analysis of microRNA precursors.
MicroRNA biogenesis occurs in several steps from their precursors having irregular hairpin structures. The highly variable architecture of these stem-and-loop structures, which have terminal loops of various sizes and diverse structure destabilizing motifs present in their stem sections, may strongly influence the process of microRNA liberation. In order to better understand this process, more ...
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MiRNAs are short non-coding RNAs that regulate gene expression. While the first miRNAs were discovered using experimental methods, experimental miRNA identification remains technically challenging and incomplete. This calls for the development of computational approaches to complement experimental approaches to miRNA gene identification. We propose in this paper a de novo miRNA precursor predic...
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Containing about 22 nucleotides, a micro RNA (abbreviated miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene expression. The human genome may encode over 1000 miRNAs. Albeit poorly characterized, miRNAs are widely deemed as important regulators of biological processes. Aberrant expression of miRNAs has been observed in many canc...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science and Engineering
سال: 2009
ISSN: 1937-6871,1937-688X
DOI: 10.4236/jbise.2009.28091